Twelve years later, human governments have concluded their campaigns against the vampires and lycans. They have annihilated 95% of the vampire race and believe lycans to be extinct. Selene, dubbed “Subject 1″, is freed from cryogenic suspension by “Subject 2″ and escapes the medical corporation Antigen. The corporation is ostensibly trying to make an antidote for the virus that creates vampires and lycans. Selene has visions that she follows, believing them to be linked to her lover, the lycan-vampire hybrid Michael Corvin. The visions lead her to a building where she is followed David, a fellow vampire. While talking with David, Selene has another vision and discovers a young girl, Eve (Subject 2). Eve is revealed to be a hybrid and the daughter of Selene and Michael. Selene and David flee the building with Eve but are attacked by a group of diseased lycans.Eve is badly wounded by one of the lycans, and David insists that they take her to his coven.